Associate Professor

Subject: Biostatistics


Solène Desmée is an Associate Professor in biostatistics.
She teaches mathematics and biostatistics at the University Technology Institute of Tours (France) and she is a researcher at SPHERE since 2017. She received her PhD in biostatistics from University Paris 7 in 2016. Her research mainly focuses on the development of statistical methods for modelling of longitudinal and survival data in particular using nonlinear joint models in the field of oncology. She also takes part to the QUARTET project on methods to analyze time-to-event outcomes in cluster randomized trials and to provide appropriate measures of clustering.

Illustration 'About-us'


Joint modelling
Nonlinear mixed effect models
Survival analysis
Cluster randomized trials


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Lewis Sheiner Student Session at PAGE (Population Approach Group in Europe) (Lisboa, Portugal)


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Using the SAEM algorithm for mechanistic joint models characterizing the relationship between nonlinear PSA kinetics and survival in prostate cancer patients.

Desmée S, Mentré F, Veyrat‐Follet C, Sébastien B, Guedj J.

2017 ; 73(1) : 305-12.
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Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer : a Comparison by Simulation of Two-Stage and Joint Approaches.

Desmée S, Mentré F, Veyrat-Follet C, Guedj J.

5 mars 2015 ; 17(3) : 691-9.
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Nonlinear joint models for individual dynamic prediction of risk of death using Hamiltonian Monte Carlo: application to metastatic prostate cancer.

Desmée S, Mentré F, Veyrat-Follet C, Sébastien B, Guedj J.

BMC Med Res Methodol
17 juillet 2017 ; 17(1) : 105.
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Bayesian inference using Hamiltonian Monte-Carlo algorithm for nonlinear joint modeling in the context of cancer immunotherapy.

Kerioui M, Mercier F, Bertrand J, Tardivon C, Bruno R, Guedj J, et al.

Stat Med
2020 ; 39(30) : 4853-68.
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Association Between Tumor Size Kinetics and Survival in Patients With Urothelial Carcinoma Treated With Atezolizumab: Implication for Patient Follow-Up.

Tardivon C, Desmée S, Kerioui M, Bruno R, Wu B, Mentré F, et al.

Clin Pharmacol Ther
2019 ; 106(4) : 810-20.
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University Technology Institute of Tours (France)
Department of Biology : mathematics, biostatistics, methodology in clinical research

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