Defended theses

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Our Theses

Management of complex patients in Pediatric Odontology: Benefit / Risk of practices and improvement pathways, focus on EMONO


The widespread use of MEOPA in dental practices is relatively recent. A review of practices and the legal framework related to the use of nitrous oxide in pediatric odontology seems so particularly relevant. In addition, the emergence of derived uses, outside the context of care or during, leads to increased vigilance towards it. It therefore seems appropriate to identify the effects felt and sought by children during inhalation of MEOPA in the context of dental care. During this thesis, we recalled the context of French use of nitrous oxide and then analyzed it against the benefit / risk of the various other sedations used in pediatric odontology. We then developed a presentation of the different works carried out, their materials and methods and their results. The whole was then discussed and future prospects considered

PhD defense date: 15/03/2021

Expression the cluster effect for binary outcomes

Ariane Murielle MBEKWE YEPNANG
Directeur(s) : Bruno GIRAUDEAU Sandra ELDRIDGE
Superviseur(s) : Agnès CAILLE

In cluster randomized trials, it is recommended to report a measure of intracluster correlation, such as the intraclass correlation coefficient (ICC), for each primary outcome.

Providing intracluster correlation estimates, which we can also call clustering estimates, may help in sample size calculation of future cluster randomized trials but also in interpreting the results of a trial. For instance, a lower intracluster correlation in the intervention arm as compared to the control one may reveal a better standardization in practices among clusters of the intervention arm, leading to a lower between-cluster heterogeneity in outcomes. Yet, when the outcome is binary, the ICC is known to be associated with the prevalence of the outcome. This may raise issues when using ICC estimates to plan a new study, because expected outcome prevalences may di er from those observed in the study from which the ICC estimates were derived. This association also challenges the interpretation of the ICC because ICC values no longer just depend on clustering level. The aim of this PhD thesis was to study several intracluster correlation measures to identify whether they depend on the outcome prevalence as the ICC does or not. We first focused on the R coefficient, a coefficient initially proposed by Rosner for ophthalmologic data and later extended by Crespi et al. who asserted that the R coefficient may be less influenced by the outcome prevalence than is the ICC. We showed by a simulation study that this assertion is false and that the R coefficient is probably even worse than the ICC as an intracluster correlation measure. We further studied other measures such as the variance partition coefficient, the median odds ratio or the tetrachoric correlation coefficient. We also proposed to consider the relative deviation of an ICC estimate to its theoretical maximum possible value. All these measures were studied in an extensive simulation study, whose conclusion was that all of them depend in some way on the outcome prevalence. Although some measures may be preferred in some situations, none outperforms the others in every situation, and none can be considered independent from the outcome prevalence. Assessing intracluster correlation independently from the outcome prevalence remains an open  eld of research.

PhD defense date: 10/12/2020

Which place for shared decision making in the context of kidney transplantation? A mixed-methods research exploring patient experience.

Directeur(s) : Leila MORET

Although kidney transplantation provides a significant benefit over dialysis, question regarding the eligibility for transplantation, the impact of replacement treatment on their lives, make the mode of renal replacement therapy a difficult decision. Therefore, Health Authority suggests shared decision-making to help patients make timely treatment modality decision. Little is known about how patient perceive their participation in the shared decision-making process. This research aims to explore the experience of patients and the factors that influence them indecision-making situations, as well as to evaluate the impact of this experience on their future. This research is based on a mixed methods research (QUANTI > quali).

It combines an interpretive phenomenological analysis and an observational study design to measure decisional conflict perceived by patients on the waiting list and to explore the factors that influence decision regret, quality of life and adherence among transplant recipients. This study reports that the experience of waiting list was identified as a necessary step in their pathway. They experienced as an implicit decision that shapes patients' attitudes towards other decisions and influences their ability to cope with the uncertainty of living with chronic kidney disease. The challenge of considering all stages of shared medical decision-making is major in the context of kidney transplantation to support patient participation decision.

PhD defense date: 30/11/2020

Discover older theses

Assessing the evolution of patient experience before and after kidney transplantation : exploring measurement invariance


End-Stage Renal Disease (ESRD) requires renal replacement therapies: dialysis or kidney transplantation.
Today, it is well-known that ESRD treatments impact the quality of life (QoL) of patients. Patients may perceive and interpret questionnaires differently over time: this phenomenon is called response shift (RS). Thus, observed changes in QoL may reflect not only a real change in QoL, but also a different perception of the questionnaires by patients over time (RS). The questionnaire’ perception and RS may also differ between patients who have experienced dialysis or not (preemptive).
The first objective of this dissertation was to evaluate and compare changes in QoL for preemptive and dialysis patients on the waiting list for kidney transplantation. The second objective was detecting and taking into account RS (before and after kidney transplantation) and measurement non-invariance between groups (dialysis and preemptive patients). To meet these objectives, several works have been realized. Thus, we have identified that QoL of dialyzed patients was generally lower than that of preemptive patients during the waiting list period.
Plus, RS has been detected, and we have observed that QoL level of patients adjusted on RS, tended to increase after kidney transplantation. Adaptation of specific therapeutic education programs for patients who have experienced dialysis or not would improve QoL of patients.

PhD defense date: 13/11/2020