Sophie
LEDUCQ

PhD students



Subject: Methodology - Biostatistics

Thesis subject

Dermatologic diseases might include one, several or multiple cutaneous lesions. They might be treated with systemic or topical drugs, according to the number of skin lesions. Different possibilities for randomized controlled trials (RCTs) assessing topical treatments can be considered. Randomization units may be the patient or his lesions; all lesions may be assessed or only one. Therefore, a classical individually RCT, a cluster RCT (in which clusters are patients, and units within clusters are lesions), or a within-person RCT might be designed. The objective of this work is to investigate methodological issues regarding RCTs assessing topical drugs in dermatologic conditions. First, we will identify and discuss key methodological issues for each design. Second, we will perform a systematic review of RCTs on topical drugs in dermatology that used a cluster design or a within-person design. Third, we will perform statistical calculations (Monte-Carlo simulations) for the study of statistical power in these 2 kinds of designs. Last, we will study the acceptance of patients and physicians for these 3 designs by using revealed preference methods.
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Publications

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Research Techniques Made Simple: Randomized Controlled Trials for Topical Drugs in Dermatology: When and How Should We Use a Within-Person Design?

Leducq S, Caille A, Le Cleach L, Samimi M, Tavernier E, Maruani A, Giraudeau B.

J Invest Dermatol.
2020 May;140(5):931-938.e1.
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Topical use of mammalian target of rapamycin inhibitors in dermatology: A systematic review with meta-analysis.

Leducq S, Giraudeau B, Tavernier E, Maruani A.

J Am Acad Dermatol.
2019 Mar;80(3):735-742.
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Efficacy and safety of methotrexate versus placebo as add-on therapy to H1 antihistamines for patients with difficult-to-treat chronic spontaneous urticaria: A randomized, controlled trial.

Leducq S, Samimi M, Bernier C, Soria A, Amsler E, Staumont-Sallé D, Gabison G, Chosidow O, Bénéton N, Bara C, Grange-Prunier A, Wierzbicka-Hainaut E, Brenaut E, Droitcourt C, Raison-Peyron N, Bourgoin H, Cornillier H, Machet L, Giraudeau B, Caille A, Maru

J Am Acad Dermatol.
2020 Jan;82(1):240-243.
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